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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
21/11/2023 |
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Data da última atualização: |
21/11/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GOUVEIA, G. C.; RIBEIRO, V. M. P.; FORTES, M. R. S.; RAIDAN, F. S. S.; REVERTER, A.; PORTO-NETO, L. R.; MORAES, M. M. de; GONÇALVES, D. R.; SILVA, M. V. G. B.; TORAL, F. L. B. |
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Afiliação: |
GABRIELA CANABRAVA GOUVEIA, UNIVERSIDADE FEDERAL DE MINAS GERAIS; VIRGÍNIA MARA PEREIRA RIBEIRO, UNIVERSIDADE FEDERAL DE MINAS GERAIS; MARINA RUFINO SALINAS FORTES, UNIVERSITY OF QUEENSLAND; FERNANDA SANTOS SILVA RAIDAN, CSIRO; ANTONIO REVERTER, CSIRO; LAERCIO RIBEIRO PORTO‑NETO, CSIRO; MARIANA MAMEDES DE MORAES, UNIVERSIDADE FEDERAL DE MINAS GERAIS; DANIEL RESENDE GONÇALVES, MUNDO NOVO FARM; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; FABIO LUIZ BURANELO TORAL, UNIVERSIDADE FEDERAL DE MINAS GERAIS. |
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Título: |
Unravelling the genetic variability of host resilience to endo and ectoparasites in Nellore commercial herds. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Genetics Selection Evolution, v. 55, article 81, 2023. |
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Idioma: |
Inglês |
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Conteúdo: |
BACKGROUND- Host resilience (HR) to parasites can afect the performance of animals. Therefore, the aim of this study was to present a detailed investigation of the genetic mechanisms of HR to ticks (TICK), gastrointestinal nematodes (GIN), and Eimeria spp. (EIM) in Nellore cattle that were raised under natural infestation and a prophylactic parasite control strategy. In our study, HR was defned as the slope coefcient of body weight (BW) when TICK, GIN, and EIM burdens were used as environmental gradients in random regression models. In total, 1712 animals were evaluated at fve measurement events (ME) at an average age of 331, 385, 443, 498, and 555 days, which generated 7307 body weight (BW) records. Of the 1712 animals, 1075 genotyped animals were used in genome-wide association studies to identify genomic regions associated with HR. RESULTS- Posterior means of the heritability estimates for BW ranged from 0.09 to 0.54 across parasites and ME. The single nucleotide polymorphism (SNP)-derived heritability for BW at each ME ranged from a low (0.09 at ME.331) to a moderate value (0.23 at ME.555). Those estimates show that genetic progress can be achieved for BW through selection. Both genetic and genomic associations between BW and HR to TICK, GIN, and EIM confrmed that parasite infestation impacted the performance of animals. Selection for BW under an environment with a controlled parasite burden is an alternative to improve both, BW and HR. There was no impact of age of measurement on the estimates of genetic variance for HR. Five quantitative trait loci (QTL) were associated with HR to EIM but none with HR to TICK and to GIN. These QTL contain genes that were previously shown to be associated with the production of antibody modulators and chemokines that are released in the intestinal epithelium. CONCLUSIONS- Selection for BW under natural infestation and controlled parasite burden, via prophylactic parasite control, contributes to the identifcation of animals that are resilient to nematodes and Eimeria ssp. Although we verifIed that sufcient genetic variation existed for HR, we did not fnd any genes associated with mechanisms that could justify the expression of HR to TICK and GIN. MenosBACKGROUND- Host resilience (HR) to parasites can afect the performance of animals. Therefore, the aim of this study was to present a detailed investigation of the genetic mechanisms of HR to ticks (TICK), gastrointestinal nematodes (GIN), and Eimeria spp. (EIM) in Nellore cattle that were raised under natural infestation and a prophylactic parasite control strategy. In our study, HR was defned as the slope coefcient of body weight (BW) when TICK, GIN, and EIM burdens were used as environmental gradients in random regression models. In total, 1712 animals were evaluated at fve measurement events (ME) at an average age of 331, 385, 443, 498, and 555 days, which generated 7307 body weight (BW) records. Of the 1712 animals, 1075 genotyped animals were used in genome-wide association studies to identify genomic regions associated with HR. RESULTS- Posterior means of the heritability estimates for BW ranged from 0.09 to 0.54 across parasites and ME. The single nucleotide polymorphism (SNP)-derived heritability for BW at each ME ranged from a low (0.09 at ME.331) to a moderate value (0.23 at ME.555). Those estimates show that genetic progress can be achieved for BW through selection. Both genetic and genomic associations between BW and HR to TICK, GIN, and EIM confrmed that parasite infestation impacted the performance of animals. Selection for BW under an environment with a controlled parasite burden is an alternative to improve both, BW and HR. There was no impact of age of meas... Mostrar Tudo |
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Palavras-Chave: |
Variabilidade genética. |
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Thesagro: |
Bovino; Gado Nelore; Hospedeiro Animal; Parasito de Animal. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1158625/1/Unravelling-the-genetic-variability-of-host-resilience-to-endo-and-ectoparasites-in-Nellore.pdf
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Marc: |
LEADER 03090naa a2200289 a 4500
001 2158625
005 2023-11-21
008 2023 bl uuuu u00u1 u #d
100 1 $aGOUVEIA, G. C.
245 $aUnravelling the genetic variability of host resilience to endo and ectoparasites in Nellore commercial herds.$h[electronic resource]
260 $c2023
520 $aBACKGROUND- Host resilience (HR) to parasites can afect the performance of animals. Therefore, the aim of this study was to present a detailed investigation of the genetic mechanisms of HR to ticks (TICK), gastrointestinal nematodes (GIN), and Eimeria spp. (EIM) in Nellore cattle that were raised under natural infestation and a prophylactic parasite control strategy. In our study, HR was defned as the slope coefcient of body weight (BW) when TICK, GIN, and EIM burdens were used as environmental gradients in random regression models. In total, 1712 animals were evaluated at fve measurement events (ME) at an average age of 331, 385, 443, 498, and 555 days, which generated 7307 body weight (BW) records. Of the 1712 animals, 1075 genotyped animals were used in genome-wide association studies to identify genomic regions associated with HR. RESULTS- Posterior means of the heritability estimates for BW ranged from 0.09 to 0.54 across parasites and ME. The single nucleotide polymorphism (SNP)-derived heritability for BW at each ME ranged from a low (0.09 at ME.331) to a moderate value (0.23 at ME.555). Those estimates show that genetic progress can be achieved for BW through selection. Both genetic and genomic associations between BW and HR to TICK, GIN, and EIM confrmed that parasite infestation impacted the performance of animals. Selection for BW under an environment with a controlled parasite burden is an alternative to improve both, BW and HR. There was no impact of age of measurement on the estimates of genetic variance for HR. Five quantitative trait loci (QTL) were associated with HR to EIM but none with HR to TICK and to GIN. These QTL contain genes that were previously shown to be associated with the production of antibody modulators and chemokines that are released in the intestinal epithelium. CONCLUSIONS- Selection for BW under natural infestation and controlled parasite burden, via prophylactic parasite control, contributes to the identifcation of animals that are resilient to nematodes and Eimeria ssp. Although we verifIed that sufcient genetic variation existed for HR, we did not fnd any genes associated with mechanisms that could justify the expression of HR to TICK and GIN.
650 $aBovino
650 $aGado Nelore
650 $aHospedeiro Animal
650 $aParasito de Animal
653 $aVariabilidade genética
700 1 $aRIBEIRO, V. M. P.
700 1 $aFORTES, M. R. S.
700 1 $aRAIDAN, F. S. S.
700 1 $aREVERTER, A.
700 1 $aPORTO-NETO, L. R.
700 1 $aMORAES, M. M. de
700 1 $aGONÇALVES, D. R.
700 1 $aSILVA, M. V. G. B.
700 1 $aTORAL, F. L. B.
773 $tGenetics Selection Evolution$gv. 55, article 81, 2023.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 5 | |
| 1. |  | RIBEIRO, V. M. P.; RAIDAN, F. S. S.; BARBOSA, A. R.; WINKELSTROTER, L. K.; SILVA, M. V. G. B.; TORAL, F. L. B. Avaliação genética multirracial via regressão aleatória com polinômios lineares do tipo spline. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 11., 2015, Santa Maria, RS. Melhoramento animal da academia ao campo: uma parceria em construção: anais. Santa Maria, RS: SBMA: UFSM, 2015. 3 p.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 2. | | RIBEIRO, V. M. P.; RAIDAN, F. S. S.; BARBOSA, A. R.; SILVA, M. V. G. B.; CARDOSO, F. F.; TORAL, F. L. B. Multiple trait and random regression models using linear splines for genetic evaluation of multiple breed populations. Journal of Dairy Science, v. 102, n. 1, p. 464-475, Jan. 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Gado de Leite; Embrapa Pecuária Sul. |
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| 3. | | FÉRES, L. F. R.; BRANDÃO, F. Z.; SANTOS, L. L.; CAMARGO, L. S. de A.; TORRES, H. A. L.; RAIDAN, F. S. S.; VIANA, J. H. M. Inbreeding and its relationship with oocyte production in the Gir (Bos indicus) breed: preliminary results. Animal Reproduction, v. 15, n. 3, p. 393, 2018. Edição dos proceedings do 32º Annual Meeting of the Brazilian Embryo Technology Society, Florianópolis, 2018.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia. |
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| 4. | | RIBEIRO, V. M. P.; GOUVEIA, G. C.; MORAES, M. M. de; ARAÚJO, A. E. M. de; RAIDAN, F. S. S.; FONSECA, P. A. de S.; CARDOSO, E. P.; SILVA, M. V. G. B.; TORAL, F. L. B. Genes underlying genetic correlation between growth, reproductive and parasite burden traits in beef cattle. Livestock Science, v. 244, 104332, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 5. | | GOUVEIA, G. C.; RIBEIRO, V. M. P.; FORTES, M. R. S.; RAIDAN, F. S. S.; REVERTER, A.; PORTO-NETO, L. R.; MORAES, M. M. de; GONÇALVES, D. R.; SILVA, M. V. G. B.; TORAL, F. L. B. Unravelling the genetic variability of host resilience to endo and ectoparasites in Nellore commercial herds. Genetics Selection Evolution, v. 55, article 81, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 5 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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